Dr. Reninger Co-authors Article Published in Cancer Medical Journal

Dr. Charles Reninger, III, M.D.

Dr. Reninger co-authors article published in cancer medical journal

Hematology and Oncology Consultants of Pennsylvania is pleased recognize Dr. Charles Reninger for co-authoring an article published in the May 2018 edition of the Journal of the National Comprehensive Cancer Care Network®.

Dr. Reninger and colleagues from the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins in Baltimore, MD, studied tumor DNA sequencing as a means to identify gene changes that can help determine targeted approaches to cancer therapy.

An abstract of the article, as appears on the National Comprehensive Cancer Care Network’s website, states:

"Tumor DNA sequencing can identify rare driver genomic alterations that suggest targets for cancer therapy, even when these drivers cannot be suspected on clinical grounds. In some cases, genomic alterations identified in the tumor can lead to a change in diagnosis with implications for prognosis and therapy. This report describes a case in which evaluation of tumor sequencing results by a molecular tumor board (MTB) led to rediagnosis of a non–small cell lung cancer as highly aggressive NUT midline carcinoma, with implications for targeted therapy using an investigational bromodomain and extraterminal (BET) inhibitor. We discuss the molecular biology and diagnosis of this rare tumor, and suggest how improved annotation of tumor sequencing reports and multidisciplinary expertise of MTBs can facilitate timely diagnosis of rare tumors and application of potential targeted therapies."

The Journal of the National Comprehensive Cancer Network is a peer-reviewed medical journal providing the latest information about best clinical practices and health services research. More than 24,000 oncologists and other cancer care professionals across the United States read the Journal.

With a special interest in genitourinary, gastrointestinal, breast, prostate and pancreatic cancers, Dr. Reninger is actively engaged in clinical research. Prior to joining Hematology and Oncology Consultant of Pennsylvania, Dr. Reninger practiced at the Naval Medical Center Portsmouth, where he served as division head and was involved in both clinical research and medical education.